Micky van de Ven Brace Halts The Toffees' Unbeaten Streak at Brand New Home Ground
The Dutch defender emerged as the initial backline player to score twice in a English top-flight match for Tottenham since Jan Vertonghen in March 2013.
Match summary
The Spurs defender heads home twice in first half
Everton's Jake O'Brien has goal disallowed after video check
Pape Matar Sarr scores third in 89th minute
This loss is Everton's initial at their new ground
The Tottenham defender found the net twice as Tottenham prolonged their winning streak on the road in the top division and delivered Everton their initial loss at Hill Dickinson Stadium.
The Toffees were undefeated in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having departed Goodison Park behind after 133 years at the conclusion of the previous campaign.
But Tottenham's leader the Dutchman pounced twice from corners in the first half to place their strong form at jeopardy, and they were failed to turn it around before the midfielder - set up by ex-Everton forward the Brazilian - nodded in a third to seal the victory.
Jake O'Brien thought he had levelled the scores five minutes after Van de Ven's first goal, directing a powerful header past the Spurs keeper from an set-piece.
Beto, in the meantime, failed to convert a handful of opportunities, while Vicario made a succession of fine stops to guarantee the London club went five away games unbeaten in the Premier League.
But the VAR stepped in, instructing Craig Pawson to check the goal on the screen and the referee ruled that Jack Grealish and Iliman Ndiaye were in offside positions and had impeded with the Spurs keeper.
This victory elevates Thomas Frank's side up to third in the Premier League, five points off local foes and leaders Arsenal.
Everton stay in 14th position and are six points clear of the drop zone.
Tottenham analysis: The defender excels in duties at both ends of the field
After a drab midweek display in the European competition against the French side, where they mustered a only two shots on goal, the manager opted for the French striker in attack instead of former Toffees player the Brazilian.
The summer signing was failed to influence the game before being substituted for Richarlison after 60 minutes on the pitch, but it turns out he proved unnecessary in the final outcome.
Centre-back Van de Ven transformed into an offensive threat to be reckoned with.
Spurs' first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur directing the ball toward the six-yard box for an free the defender to head home.
And the captain - stepping up as captain in Cristian Romero's absence - notched his next goal in added time as he outjumped Jordan Pickford to head home.
The Dutchman was equally impressive in defensive duties, combining effectively with Kevin Danso as the pair handled excellently with the numerous deliveries sent their way by Everton.
Toffees breakdown: Everton missing striker's instinct
Everton's new home had been a fortress, but it seems the novelty may have faded slightly and fans headed to the gates after Sarr's final goal for Tottenham.
The break in Everton's unbeaten home run won't be a major worry for the manager, but their striker situation are.
The forward and the other striker - the Everton's pair of recognised strikers - had scored just one league goal combined before Sunday's outing.
And they were failed to add to that miserable tally on a damp and dreary night on in Liverpool.
The striker's form was summed up when he chose to overhead kick a clear chance from close range, despite having room and time to reposition for a more conventional attempt that would have tested Vicario.
Barry, too, failed to influence the game after replacing Beto in the second half.
It was not for a lack of chance. Most of the home side's attacks came through Grealish and Ndiaye, who relentlessly delivered threatening balls into the Tottenham penalty area.
What next for these two sides?
Everton: The team travel to Sunderland in the top flight on early November at 20:00 GMT.
Spurs: Spurs travel to Newcastle's ground on Wednesday, 29 October for their next round League Cup match against the Magpies.